NeoFill PLLA Filler 200mg

Aliphatic Thermoplastic Polymer Made from 100% Renewable Raw Materials Such as Corn and Potato Starch

PLLA (Poly-L-Lactic Acid, Polylactide) is an aliphatic thermoplastic polymer derived from 100% renewable resources.

PLA (Polylactic acid): Lactic acid has two optical isomers: L-lactic acid and D-lactic acid, with similar chemical and physical properties.

PLA is 100% biodegradable in the body after its function is complete.

* Chemical Formula of Lactic Acid: C3H6O3

Optical Lactic Acid Monomers

Optical isomers (enantiomer) Right- and left-handed mirror image isomers of a chiral molecule have the same molecular formula but different atomic arrangements. Monomers A monomer is a low molecular weight molecule that forms a polymer. A polymer can consist of multiple monomers.

Filler with the Longest Action Stimulates Collagen Synthesis and Skin Regeneration for More than 2 Years

PLLA: A natural polymer component that has a longer lasting effect than HA fillers due to the induction of collagen production and natural degradation in the body over a period of 2.5-3 years.

Neophyl Mechanism 1 Immediate Wrinkle Reduction After Injection PLLA Particles Fill Space Restoring Lost Volume

Mechanism 1. Volume enhancement by injecting PLLA filler into the dermis to restore lost volume

At 1-2 weeks after injection, there is a loss of volume, but at 4-8 weeks, cell and collagen production restores volume.

Collagen is produced gradually over time as cells flow into the porous PLLA particles.

Collagen is Synthesized to Form New Tissue New Skin Cells Migrate to PLLA Particles, Which Decompose into H2O and CO2

PLLA - Safe Material, FDA Approved 100% Biodegradable Material, Removable by Hydrolysis

New Cells Are Observed Already From the 2nd Week At 12 Weeks Cells Begin to Migrate to the Internal Parts of the PLLA Particles

The formation of collagen leads to the formation of new tissue. Beginning in the 4th week, cells lodged in the PLLA produce new collagen.

At the 2nd week after injection, active growth of cells migrating to the surface of the PLLA particles begins. These cells fill the empty space between particles.

At week 8, all the voids between the PLLA particles are filled with cells, which begin to penetrate the pores of the PLLA particles. (Indicated by yellow arrows)

At the 12th and 20th weeks of the cell, PLLA migrates into the particles, filling their interior.

After injection, the filler remains in the same layer without migrating to other tissues or areas, as shown above in the image at 2 and 4 weeks after injection

Duration of action of Neophyl More than 24 months Action of PLLA Fillers is 2 Times Longer than that of GC Fillers and Other Materials

Application Areas Recommended Apply Evenly All Over Face Focus on Nasolabial Folds and Crow's Feet to Improve Skin Texture

Purpose ⁻ Primary purpose: Dryness, Thin skin with shallow wrinkles ⁻ Secondary purpose: Crow's feet, nasolabial folds

Effect ⁻ General increase in volume due to collagenesis, i.e. stimulating the production of new collagen under the skin.

It only takes 20 minutes to suspend, enter deep into the skin and massage the area for even distribution.

Application

To prepare a 9 ml solution, 30 minutes before the procedure, add 7 ml of sterile Water for Injection (SWFI) and 2 ml of lidocaine into the Neophyl vial. ※Different protocols are possible by adjusting the amount of filler and SWFI.

Inject into the deep layers of the dermis, just above the Subcutaneous Fat Layer (which is deeper than other fillers), where the most active collagen production occurs

When preparing the solution, use an 18G needle; for the procedure, it is recommended to use a sterile cannula from 26G to 28G.

The injection is made above the Subcutaneous Fat Layer to enhance the lifting effect and tighten the skin tissue.

It is recommended to inject 1 ml into the injection area.

Volume 1 Bottle – 200 mg

Application Volume restoration, Wrinkle improvement, Lifting

Component PLLA (Poly-L-Lactic Acid) 200 mg/bottle

Packaging 1 bottle/pack (10 packs/CT)

Dimensions (L x H x W) 3.6 x 3.0 x 6.2 cm Weight 20 g

Shelf life: 2 years (Store at room temperature)

Frequency of procedure 3~4 times with an interval of 1 month

Effect duration 24~32 months